GenAge entry for AR (Homo sapiens)

Gene name (HAGRID: 110)

HGNC symbol: AR
Aliases: AIS; NR3C4; SMAX1; HUMARA; DHTR; SBMA
Common name: androgen receptor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: AR is involved in transcriptional regulation and cellular proliferation and differentiation [576]. Disruption of AR in mice results in insulin (INS) and leptin (LEP) resistance, which suggests that AR may contribute to certain age-related diseases such as type 2 diabetes and cardiovascular disease [1331]. Its exact role in human ageing is unknown.

Cytogenetic information

Cytogenetic band: Xq12
Location: 67,544,032 bp to 67,730,619 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001701; in utero embryonic development
GO:0003073; regulation of systemic arterial blood pressure
GO:0003382; epithelial cell morphogenesis
GO:0006351; transcription, DNA-templated
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006810; transport
GO:0007165; signal transduction
GO:0007267; cell-cell signaling
GO:0007283; spermatogenesis
GO:0007338; single fertilization
GO:0007548; sex differentiation

And 41 more GO terms

Cellular component:

GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0043234; protein complex

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085; RNA polymerase II transcription factor binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004879; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0004882; androgen receptor activity
GO:0005102; receptor binding
GO:0005496; steroid binding
GO:0005497; androgen binding

And 10 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ERCC2, E2F1, STAT3, HDAC3, AKT1, EGFR, NCOR1, BRCA1, PTEN, CREBBP, VCP, HSP90AA1, UBE2I, CEBPA, CEBPB, EP300, GSK3B, ERCC3, PRKDC, AR, GTF2H2, XRCC5, XRCC6, RB1, FOXO1, RELA, SIRT1, HDAC1, HSPA1A, SP1, JUN, MED1, HMGB1, HMGB2, TAF1, BMI1, TBP, SIN3A, MDM2, CTNNB1, PPP1CA, STUB1, NCOR2, GSK3A, CDK7
STRING interaction network

Retrieve sequences for AR

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ar
Mus musculus: Ar
Rattus norvegicus: Ar

In other databases

CellAge

This gene is present as AR