GenAge entry for FOS (Homo sapiens)

Gene name (HAGRID: 50)

HGNC symbol: FOS
Aliases: c-fos; AP-1
Common name: FBJ murine osteosarcoma viral oncogene homolog

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: The FOS oncogene plays an important role in development, cell proliferation, and differentiation [118]. As part of the AP-1 transcriptional complex, FOS has been associated with age-related changes and with the attenuated cellular response in older cells [851]. Still, its relevance to human ageing remains under debate.

Cytogenetic information

Cytogenetic band: 14q24.3
Location: 75,278,778 bp to 75,282,234 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001661; conditioned taste aversion
GO:0006306; DNA methylation
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006954; inflammatory response
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007399; nervous system development
GO:0007565; female pregnancy
GO:0007568; aging
GO:0009409; response to cold
GO:0009416; response to light stimulus

And 24 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0016020; membrane
GO:0043005; neuron projection

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0044212; transcription regulatory region DNA binding
GO:0046982; protein heterodimerization activity
GO:0070412; R-SMAD binding

And 1 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, JUND, FOS, CREBBP, ABL1, UBE2I, CEBPA, EP300, PML, RB1, APP, RELA, SIRT1, HSPA1A, JUN, MAPK9, TAF1, ATF2, TBP, DDIT3, ESR1, CLU, CHEK2, NCOR2
STRING interaction network

Retrieve sequences for FOS

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: fos
Mus musculus: Fos
Rattus norvegicus: Fos

In other databases

CellAge

This gene is present as FOS