GenAge entry for BUB1B (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 197)

HGNC symbol: BUB1B
Aliases: BUBR1; MAD3L; Bub1A; SSK1
Common name: BUB1 mitotic checkpoint serine/threonine kinase B

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: BUB1B is a mitotic checkpoint that controls chromosome segregation and maintains genetic stability [1080]. BUB1B-null mice die at embryonic stages [1081], but accelerated ageing has been reported in mice with BUB1B insufficiency [1082]. Overexpression of BubR1, in mice, preserves genomic integrity, reduces tumorigenesis and extends average and maximum lifespan by 14% and 18%, respectively [3267]. In humans, mutations in the BUB1B gene have been associated with cancer [1733].

Cytogenetic information

Cytogenetic band: 15q15
Location: 40,161,009 bp to 40,221,136 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0007062; sister chromatid cohesion
GO:0007067; mitotic nuclear division
GO:0007091; metaphase/anaphase transition of mitotic cell cycle
GO:0007093; mitotic cell cycle checkpoint
GO:0007094; mitotic spindle assembly checkpoint
GO:0008283; cell proliferation
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0034501; protein localization to kinetochore
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051301; cell division
GO:0051436; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition

Cellular component:

GO:0000776; kinetochore
GO:0000777; condensed chromosome kinetochore
GO:0000778; condensed nuclear chromosome kinetochore
GO:0000940; condensed chromosome outer kinetochore
GO:0005680; anaphase-promoting complex
GO:0005737; cytoplasm
GO:0005815; microtubule organizing center
GO:0005829; cytosol
GO:0048471; perinuclear region of cytoplasm
GO:0051233; spindle midzone

Function:

GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PARP1, BRCA2, MXI1, EEF2, SNCG, HDAC1, CCNA2, BUB1B, MDM2, SUMO1, BUB3, RAE1, TP73
STRING interaction network

Retrieve sequences for BUB1B

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: si:ch1073-192f24.1
Mus musculus: Bub1b
Rattus norvegicus: Bub1b
Schizosaccharomyces pombe: bub1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Bub1b

CellAge

This gene is present as BUB1B

CellAge gene expression

This gene is present as BUB1B