GenAge entry for PIN1 (Homo sapiens)

Gene name (HAGRID: 62)

HGNC symbol: PIN1
Aliases: dod
Common name: peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: Important for the regulation of mitosis and cell cycle progression, PIN1 is critical for TP53 function [424]. Some results indicate that PIN1 plays a role in protecting against neurodegenerative diseases [421], and PIN1 regulates APP processing, suggesting a possible role in Alzheimer's disease [1621]. Although PIN1 has not been directly related to ageing, it is a promising avenue of research, at least in relation to neurodegeneration.

Cytogenetic information

Cytogenetic band: 19p13
Location: 9,835,207 bp to 9,849,689 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000413; protein peptidyl-prolyl isomerization
GO:0001934; positive regulation of protein phosphorylation
GO:0007049; cell cycle
GO:0007088; regulation of mitotic nuclear division
GO:0030182; neuron differentiation
GO:0030512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032091; negative regulation of protein binding
GO:0032465; regulation of cytokinesis
GO:0032480; negative regulation of type I interferon production
GO:0035307; positive regulation of protein dephosphorylation
GO:0042177; negative regulation of protein catabolic process
GO:0043524; negative regulation of neuron apoptotic process
GO:0043525; positive regulation of neuron apoptotic process
GO:0043547; positive regulation of GTPase activity
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0050808; synapse organization
GO:0050821; protein stabilization
GO:0051443; positive regulation of ubiquitin-protein transferase activity
GO:0060393; regulation of pathway-restricted SMAD protein phosphorylation
GO:0061051; positive regulation of cell growth involved in cardiac muscle cell development
GO:0070373; negative regulation of ERK1 and ERK2 cascade
GO:0090263; positive regulation of canonical Wnt signaling pathway
GO:1900180; regulation of protein localization to nucleus
GO:1901796; regulation of signal transduction by p53 class mediator
GO:2000146; negative regulation of cell motility

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0016607; nuclear speck
GO:0030496; midbody
GO:0043005; neuron projection

Function:

GO:0003755; peptidyl-prolyl cis-trans isomerase activity
GO:0003774; motor activity
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0031434; mitogen-activated protein kinase kinase binding
GO:0032794; GTPase activating protein binding
GO:0050815; phosphoserine binding
GO:0050816; phosphothreonine binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, HDAC3, MYC, ERBB2, BCL2, TOP2A, EP300, PML, XRCC6, SOD1, RELA, HDAC1, SP1, JUN, MED1, FOXO4, MAPT, LEPR, NFKBIA, CTNNB1, GPX4, PPARG, TP73
STRING interaction network

Retrieve sequences for PIN1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: pinn-1
Danio rerio: pin1
Drosophila melanogaster: dod
Mus musculus: Pin1
Rattus norvegicus: LOC364561
Saccharomyces cerevisiae: ESS1
Schizosaccharomyces pombe: pin1

In other databases

CellAge

This gene is present as PIN1