GenAge entry for RPA1 (Homo sapiens)

Gene name (HAGRID: 67)

HGNC symbol: RPA1
Aliases: REPA1; RPA70; HSSB; RF-A; RP-A
Common name: replication protein A1, 70kDa

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: RPA1 is involved in replication, recombination, and DNA repair. Due to its involvement with ageing-related genes, such as WRN [441], RPA1 has been hinted as a player in the ageing process. Nonetheless, there is no direct evidence that RPA1 is linked to human ageing.

Cytogenetic information

Cytogenetic band: 17p13.3
Location: 1,829,979 bp to 1,899,554 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000082; G1/S transition of mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0000724; double-strand break repair via homologous recombination
GO:0006260; DNA replication
GO:0006261; DNA-dependent DNA replication
GO:0006281; DNA repair
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006284; base-excision repair
GO:0006289; nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006298; mismatch repair
GO:0006310; DNA recombination
GO:0016925; protein sumoylation
GO:0019985; translesion synthesis
GO:0033683; nucleotide-excision repair, DNA incision
GO:0036297; interstrand cross-link repair
GO:0042276; error-prone translesion synthesis
GO:0042769; DNA damage response, detection of DNA damage
GO:0070987; error-free translesion synthesis
GO:1900034; regulation of cellular response to heat
GO:1901796; regulation of signal transduction by p53 class mediator

Cellular component:

GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005662; DNA replication factor A complex
GO:0016605; PML body

Function:

GO:0003684; damaged DNA binding
GO:0003697; single-stranded DNA binding
GO:0005515; protein binding
GO:0046872; metal ion binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, WRN, LMNA, EGFR, NBN, PARP1, BRCA1, RPA1, BLM, BRCA2, TOP2A, TOP2B, RAD51, ERCC6, PRKDC, XRCC5, PCNA, TERF2, XRCC6, POLD1, XPA, PRDX1, RAD52, TOP3B, CCNA2, LMNB1, EEF1A1, APEX1, HSPA8, CDK1, POLA1, ATR, BUB3, TP53BP1, CDK7, SPRTN
STRING interaction network

Retrieve sequences for RPA1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: rpa-1
Danio rerio: rpa1
Drosophila melanogaster: RpA-70
Mus musculus: Rpa1
Rattus norvegicus: Rpa1
Saccharomyces cerevisiae: RFA1
Schizosaccharomyces pombe: ssb1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as rpa-1

LongevityMap

This gene is present as RPA1