GenAge entry for CLU (Homo sapiens)

Gene name (HAGRID: 220)

HGNC symbol: CLU
Aliases: SGP-2; SP-40; TRPM-2; KUB1; CLU1; CLU2; CLI; APOJ
Common name: clusterin

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Description

The functions of CLU are still unclear, but it may be involved in apoptosis. In flies, overexpression of human clusterin increased stress resistance and significantly extended lifespan [2116]. CLU-null mice had 50% less brain injury following neonatal hypoxia-ischemia [1748]. Inflammation was more severe in CLU-deficient mice [1749].

In humans, serum levels of CLU increase during type 2 diabetes and coronary heart disease [1230] and genome-wide association studies have identified variants of CLU to be associated with Alzheimer's disease [2003][2004]. There is however no direct evidence linking CLU to human ageing.

Cytogenetic information

Cytogenetic band: 8p21-p12
Location: 27,596,917 bp to 27,615,031 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000902; cell morphogenesis
GO:0001774; microglial cell activation
GO:0001836; release of cytochrome c from mitochondria
GO:0002576; platelet degranulation
GO:0006629; lipid metabolic process
GO:0006956; complement activation
GO:0006958; complement activation, classical pathway
GO:0009615; response to virus
GO:0017038; protein import
GO:0032286; central nervous system myelin maintenance
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463; negative regulation of protein homooligomerization
GO:0032760; positive regulation of tumor necrosis factor production
GO:0043691; reverse cholesterol transport
GO:0045087; innate immune response
GO:0045429; positive regulation of nitric oxide biosynthetic process
GO:0050821; protein stabilization
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0051131; chaperone-mediated protein complex assembly
GO:0051788; response to misfolded protein
GO:0061077; chaperone-mediated protein folding
GO:0061518; microglial cell proliferation
GO:1900221; regulation of beta-amyloid clearance
GO:1901214; regulation of neuron death
GO:1901216; positive regulation of neuron death
GO:1902004; positive regulation of beta-amyloid formation
GO:1902230; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430; negative regulation of beta-amyloid formation
GO:1902847; regulation of neuronal signal transduction
GO:1902949; positive regulation of tau-protein kinase activity
GO:1902998; positive regulation of neurofibrillary tangle assembly
GO:2000060; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0009986; cell surface
GO:0031012; extracellular matrix
GO:0031093; platelet alpha granule lumen
GO:0031966; mitochondrial membrane
GO:0034366; spherical high-density lipoprotein particle
GO:0042583; chromaffin granule
GO:0043234; protein complex
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome
GO:0072562; blood microparticle
GO:0097418; neurofibrillary tangle
GO:0097440; apical dendrite

Function:

GO:0005515; protein binding
GO:0016887; ATPase activity
GO:0031625; ubiquitin protein ligase binding
GO:0051087; chaperone binding
GO:0051787; misfolded protein binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, FOS, NFKB1, TNF, XRCC6, BAX, GRB2, LRP2, APP, PON1, HSPD1, MAPK9, MDM2, H2AFX, NFKBIA, CLU, ELN, PDGFRA
STRING interaction network

Retrieve sequences for CLU

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: clu
Mus musculus: Clu
Rattus norvegicus: Clu

In other databases

GenAge microarray genes

This gene is present as CLU

LongevityMap

This gene is present as CLU

CellAge

This gene is present as CLU