GenAge entry for MAPK8 (Homo sapiens)
Gene name (HAGRID: 163)
- HGNC symbol
- MAPK8
- Aliases
- JNK; JNK1; SAPK1; PRKM8
- Common name
- mitogen-activated protein kinase 8
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
MAPK8, also known as JNK1, encodes many transcripts and is an important player in stress response. In invertebrates, there is evidence linking JNK signalling to ageing. Fruit flies with mutations that augment JNK signalling live longer [212]. Overexpression of JNK in roundworms also increases lifespan [60]. Changes in JNK1 with age have been reported in rat hepatocytes [768]. MAPK8-null mice showed defective T cell differentiation [761]. Mice without MAPK8 and MAPK9 die at embryonic stages [1715]. In mouse models of obesity, absence of MAPK8 decreased adiposity and improved insulin (INS) sensitivity [765]. Although MAPK8 could play a role in ageing-related diseases, further research is needed to determine how MAPK8 is related to human ageing.
Cytogenetic information
- Cytogenetic band
- 10q11.22
- Location
- 48,401,612 bp to 48,439,359 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006468; protein phosphorylation
GO:0006950; response to stress
GO:0007254; JNK cascade
GO:0007258; JUN phosphorylation
GO:0009411; response to UV
GO:0010628; positive regulation of gene expression
GO:0016241; regulation of macroautophagy
GO:0018105; peptidyl-serine phosphorylation
GO:0018107; peptidyl-threonine phosphorylation
GO:0031063; regulation of histone deacetylation
GO:0031281; positive regulation of cyclase activity
GO:0032091; negative regulation of protein binding
GO:0032880; regulation of protein localization
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0042752; regulation of circadian rhythm
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0048511; rhythmic process
GO:0051090; regulation of sequence-specific DNA binding transcription factor activity
GO:0051247; positive regulation of protein metabolic process
GO:0071222; cellular response to lipopolysaccharide
GO:0071260; cellular response to mechanical stimulus
GO:0090045; positive regulation of deacetylase activity
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
Hide GO termsFunction: GO:0004674; protein serine/threonine kinase activity
GO:0004705; JUN kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0019899; enzyme binding
GO:0035033; histone deacetylase regulator activity
GO:0042826; histone deacetylase binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, STAT3, IRS1, AKT1, HRAS, MYC, EGFR, JUND, BCL2, PDPK1, CEBPA, EP300, PRKDC, FAS, RB1, HSF1, APP, SNCG, SIRT1, HDAC1, GSTP1, MAPK8, YWHAZ, SP1, JUN, MAPK9, ATF2, HSPA8, MAPT, H2AFX, MTOR, CTNNB1, CDKN2A, CDC42, NFE2L2, CDKN1A
- STRING interaction network
