GenAge entry for HSPA8 (Homo sapiens)
Gene name (HAGRID: 199)
- HGNC symbol
- HSPA8
- Aliases
- HSC71; HSC70; HSP73; HSPA10
- Common name
- heat shock 70kDa protein 8
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Also called hsc70 and hsp73, HSPA8 is a constitutively expressed chaperone. Age-related changes in stress response have been reported in rats, though HSPA8 levels do not appear to change with age [915]. Whether HSPA8 plays any role in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 11q24.1
- Location
- 123,057,492 bp to 123,062,335 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000398; mRNA splicing, via spliceosome
GO:0006351; transcription, DNA-templated
GO:0006457; protein folding
GO:0006986; response to unfolded protein
GO:0007269; neurotransmitter secretion
GO:0009267; cellular response to starvation
GO:0016032; viral process
GO:0031647; regulation of protein stability
GO:0042026; protein refolding
GO:0043254; regulation of protein complex assembly
GO:0043488; regulation of mRNA stability
GO:0044829; positive regulation by host of viral genome replication
GO:0045892; negative regulation of transcription, DNA-templated
GO:0046034; ATP metabolic process
GO:0048026; positive regulation of mRNA splicing, via spliceosome
GO:0051085; chaperone mediated protein folding requiring cofactor
GO:0051726; regulation of cell cycle
GO:0061635; regulation of protein complex stability
GO:0061684; chaperone-mediated autophagy
GO:0061738; late endosomal microautophagy
GO:0061740; protein targeting to lysosome involved in chaperone-mediated autophagy
GO:0061741; chaperone-mediated protein transport involved in chaperone-mediated autophagy
GO:0072318; clathrin coat disassembly
GO:0098609; cell-cell adhesion
GO:1900034; regulation of cellular response to heat
GO:1902904; negative regulation of supramolecular fiber organization
GO:1904589; regulation of protein import
GO:1904764; chaperone-mediated autophagy translocation complex disassembly
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0000974; Prp19 complex
GO:0005615; extracellular space
GO:0005622; intracellular
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005681; spliceosomal complex
GO:0005730; nucleolus
GO:0005765; lysosomal membrane
GO:0005770; late endosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0005925; focal adhesion
GO:0016020; membrane
GO:0030529; intracellular ribonucleoprotein complex
GO:0031012; extracellular matrix
GO:0042470; melanosome
GO:0043202; lysosomal lumen
GO:0043209; myelin sheath
GO:0061202; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062; extracellular exosome
GO:0072562; blood microparticle
GO:0098575; lumenal side of lysosomal membrane
GO:0098793; presynapse
Hide GO termsFunction: GO:0001664; G-protein coupled receptor binding
GO:0001786; phosphatidylserine binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0019899; enzyme binding
GO:0023026; MHC class II protein complex binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0042623; ATPase activity, coupled
GO:0044822; poly(A) RNA binding
GO:0051082; unfolded protein binding
GO:0055131; C3HC4-type RING finger domain binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TP53, ATM, HDAC3, AKT1, EGFR, BRCA1, PTEN, HIF1A, RPA1, VCP, HSP90AA1, ABL1, HTT, EEF2, PRKDC, GRB2, HSF1, SOD1, UCHL1, APP, RELA, RAD52, HSPA9, HSPD1, HSPA1A, MAPK8, JUN, HMGB1, LMNB1, EEF1A1, MAPT, MDM2, JAK2, ESR1, CTNNB1, CDKN2A, PPP1CA, SIRT6, STUB1, CDKN1A, SPRTN
- STRING interaction network
