GenAge entry for JUN (Homo sapiens)

Gene name (HAGRID: 172)

HGNC symbol: JUN
Aliases: c-Jun; AP-1
Common name: jun proto-oncogene

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: JUN is an important transcription factor that is also a member of the AP-1 transcriptional complex. Its signalling pathway has been related to ageing in fruit flies [212] and roundworms [60], though a direct role of JUN has not been demonstrated. Results from mice have shown that AP-1's DNA-binding activity decreases with age [837]. JUN-null mice die at embryonic stages [783]. Further research is needed to assess JUN'1 role in human ageing.

Cytogenetic information

Cytogenetic band: 1p32-p31
Location: 58,780,791 bp to 58,784,113 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001525; angiogenesis
GO:0001774; microglial cell activation
GO:0001836; release of cytochrome c from mitochondria
GO:0001889; liver development
GO:0001938; positive regulation of endothelial cell proliferation
GO:0003151; outflow tract morphogenesis
GO:0006366; transcription from RNA polymerase II promoter
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007184; SMAD protein import into nucleus
GO:0007265; Ras protein signal transduction
GO:0007568; aging

And 46 more GO terms

Cellular component:

GO:0000228; nuclear chromosome
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005719; nuclear euchromatin
GO:0005829; cytosol
GO:0017053; transcriptional repressor complex

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

And 14 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: POU1F1, STAT3, HDAC3, MYC, NCOR1, JUND, FOS, PARP1, BRCA1, PIN1, CREBBP, HIF1A, HSP90AA1, NR3C1, ABL1, TOP2A, UBE2I, CEBPA, CEBPB, EP300, PML, GSK3B, PRKDC, AR, RB1, APP, RELA, SIRT1, HDAC1, MAPK8, MAPK14, SP1, JUN, MAPK9, MAPK3, TAF1, TFAP2A, CREB1, ATF2, TBP, HSPA8, DDIT3, MDM2, SUMO1, ESR1, PPARG, NCOR2, NFE2L2, CDKN1A, IKBKB, NFE2L1
STRING interaction network

Retrieve sequences for JUN

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: jun
Mus musculus: Jun
Rattus norvegicus: Jun

In other databases

CellAge

This gene is present as JUN