GenAge entry for UBE2I (Homo sapiens)

Gene name (HAGRID: 85)

HGNC symbol: UBE2I
Aliases: UBC9
Common name: ubiquitin-conjugating enzyme E2I

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: UBE2I catalyzes the attachment of SUMO1 to other proteins. Although no direct evidence exists to suggest a role for UBE2I in ageing, it is related to, among others, WRN [903] and PCNA [490], suggesting it might play a role in DNA repair and perhaps even in ageing. UBE2I deficiency in mice results in embryonic lethality [1678].

Cytogenetic information

Cytogenetic band: 16p13.3
Location: 1,309,627 bp to 1,327,018 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006464; cellular protein modification process
GO:0006511; ubiquitin-dependent protein catabolic process
GO:0007059; chromosome segregation
GO:0007067; mitotic nuclear division
GO:0016032; viral process
GO:0016925; protein sumoylation
GO:0043123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045892; negative regulation of transcription, DNA-templated
GO:0051301; cell division
GO:0070911; global genome nucleotide-excision repair
GO:1903755; positive regulation of SUMO transferase activity

Cellular component:

GO:0000795; synaptonemal complex
GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016605; PML body
GO:1990234; transferase complex
GO:1990356; sumoylated E2 ligase complex

Function:

GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding
GO:0016874; ligase activity
GO:0019789; SUMO transferase activity
GO:0019899; enzyme binding
GO:0031625; ubiquitin protein ligase binding
GO:0043398; HLH domain binding
GO:0044822; poly(A) RNA binding
GO:0061630; ubiquitin protein ligase activity
GO:0061656; SUMO conjugating enzyme activity
GO:0071535; RING-like zinc finger domain binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, LMNA, MYC, NCOR1, EGF, FOS, PPARA, TCF3, PARP1, BRCA1, PTEN, CREBBP, HIF1A, BLM, BCL2, NR3C1, TOP2A, TOP2B, TOP1, RAD51, UBE2I, EP300, PML, PRKDC, AR, XRCC5, FAS, TERF2, RB1, HSF1, FOXM1, UCHL1, APP, RAD52, SIRT1, HDAC1, JUN, TAF1, BMI1, TFAP2A, CREB1, ATF2, TBP, APEX1, CDK1, MDM2, SUMO1, ESR1, NFKBIA, CDKN2A, TP63, HIC1, PPARGC1A, PPARG, TP53BP1, NCOR2, TP73
STRING interaction network

Retrieve sequences for UBE2I

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: ubc-9
Danio rerio: ube2ib
Drosophila melanogaster: lwr
Mus musculus: Ube2i
Rattus norvegicus: Ube2i
Saccharomyces cerevisiae: UBC9
Schizosaccharomyces pombe: hus5

In other databases

CellAge

This gene is present as UBE2I