GenAge entry for ESR1 (Homo sapiens)

Gene name (HAGRID: 216)

HGNC symbol: ESR1
Aliases: NR3A1; Era; ESR
Common name: estrogen receptor 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: ESR1 is a transcription factor that mediates the actions of estrogen. Mice without ESR1 were infertile and showed a variety of changes [1193]. Polymorphisms in the human ESR1 gene have been associated with cardiovascular disease [1740]. ESR1 has also been found to be upregulated in Alzheimer's disease [1185]. A role for ESR1 in human ageing is plausible though at present largely obscure.

Cytogenetic information

Cytogenetic band: 6q25.1
Location: 151,807,678 bp to 152,103,273 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001547; antral ovarian follicle growth
GO:0002064; epithelial cell development
GO:0006338; chromatin remodeling
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0007165; signal transduction
GO:0007200; phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204; positive regulation of cytosolic calcium ion concentration

And 30 more GO terms

Cellular component:

GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0016021; integral component of membrane
GO:0035327; transcriptionally active chromatin

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046; core promoter sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003707; steroid hormone receptor activity
GO:0005496; steroid binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008134; transcription factor binding
GO:0008270; zinc ion binding

And 8 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, IGF1R, STAT3, STAT5A, IRS1, IRS2, AKT1, MYC, EGFR, ERBB2, FOS, HDAC3, PARP1, BRCA1, PTEN, CREBBP, HIF1A, NCOR1, HSP90AA1, TOP2A, TOP2B, TOP1, RAD51, UBE2I, EP300, EEF2, PRKDC, CAT, XRCC5, XRCC6, HSPA8, EMD, FOXO1, AIFM1, SIRT1, HDAC1, HSPD1, SP1, JUN, MED1, FOXO4, PIK3R1, TBP, HBP1, SIN3A, E2F1, HDAC2, MDM2, RELA, VCP, H2AFX, CEBPA, CEBPB, ESR1, CTNNB1, DBN1, PPP1CA, STUB1, PPARGC1A, NCOR2, CDKN1A, PIK3CA, CDK7
STRING interaction network

Retrieve sequences for ESR1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: esr1
Mus musculus: Esr1
Rattus norvegicus: Esr1

In other databases

LongevityMap

This gene is present as ESR1

CellAge

This gene is present as ESR1