GenAge entry for CREBBP (Homo sapiens)

Gene name (HAGRID: 64)

HGNC symbol: CREBBP
Aliases: RTS; CBP; KAT3A; RSTS
Common name: CREB binding protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: A transcriptional regulatory protein, CREBBP acetylates histones and mediates cAMP-gene regulation by binding to phosphorylated CREB1. CREBBP null mice die during embryogenesis, but heterozygous animals exhibit lipodystrophy, have increased insulin (INS) and leptin (LEP) sensitivity, and appear to be protected from weight gain induced by a high-fat diet [429]. In humans, defects in CREBBP have been associated with Rubinstein-Taybi syndrome [428]. Its important roles in transcriptional regulation and its large number of interacting partners suggest CREBBP might potentially be involved in some aspects of ageing.

Cytogenetic information

Cytogenetic band: 16p13.3
Location: 3,725,055 bp to 3,880,120 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001666; response to hypoxia
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006355; regulation of transcription, DNA-templated
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006461; protein complex assembly
GO:0006473; protein acetylation
GO:0007165; signal transduction
GO:0007219; Notch signaling pathway
GO:0008589; regulation of smoothened signaling pathway
GO:0016032; viral process
GO:0016573; histone acetylation
GO:0018076; N-terminal peptidyl-lysine acetylation
GO:0032481; positive regulation of type I interferon production
GO:0034644; cellular response to UV
GO:0042592; homeostatic process
GO:0042733; embryonic digit morphogenesis
GO:0042981; regulation of apoptotic process
GO:0044255; cellular lipid metabolic process
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048511; rhythmic process
GO:0061418; regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:1900034; regulation of cellular response to heat
GO:1904837; beta-catenin-TCF complex assembly

Cellular component:

GO:0000123; histone acetyltransferase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016604; nuclear body

Function:

GO:0000987; core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085; RNA polymerase II transcription factor binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001105; RNA polymerase II transcription coactivator activity
GO:0001191; transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0002039; p53 binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0004402; histone acetyltransferase activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008270; zinc ion binding
GO:0016407; acetyltransferase activity
GO:0034212; peptide N-acetyltransferase activity
GO:0043426; MRF binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: POU1F1, TP53, WRN, STAT3, AKT1, MYC, FOS, HDAC3, PARP1, BRCA1, CREBBP, HIF1A, NCOR1, EGR1, UBE2I, EP300, PML, HTT, AR, PCNA, XRCC6, FOXO3, FOXO1, HSF1, FOXM1, HDAC1, FGFR1, SP1, JUN, MAPK3, HMGB1, CCNA2, HMGB2, MAP3K5, FOXO4, BMI1, CREB1, ATF2, TBP, HBP1, TFDP1, E2F1, HDAC2, MDM2, DDIT3, RELA, TCF3, SUMO1, HOXB7, NR3C1, CEBPB, ESR1, CTNNB1, ARNTL, CLOCK, PPARGC1A, PPARG, NCOR2, TP73, NFE2L2, CDKN1A, IKBKB
STRING interaction network

Retrieve sequences for CREBBP

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: cbp-1
Danio rerio: crebbpb
Drosophila melanogaster: nej
Mus musculus: Crebbp
Rattus norvegicus: Crebbp

In other databases

GenDR gene manipulations

A homolog of this gene for Caenorhabditis elegans is present as cbp-1