Human Ageing-Associated Genes

HAGRID	HGNC symbol	Common name	Display entry	Source
8	TERT	telomerase reverse transcriptase	TERT	cell,functional
16	TXN	thioredoxin	TXN	model,functional
20	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	NFKB2	functional
26	GH1	growth hormone 1	GH1	mammal,functional,downstream
28	IGF1	insulin-like growth factor 1 (somatomedin C)	IGF1	functional
29	IGF2	insulin-like growth factor 2	IGF2	functional
30	INS	insulin	INS	functional
58	PEX5	peroxisomal biogenesis factor 5	PEX5	functional
25	HDAC3	histone deacetylase 3	HDAC3	functional
60	PARP1	poly (ADP-ribose) polymerase 1	PARP1	functional,putative
65	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	HIF1A	functional,downstream
68	BLM	Bloom syndrome, RecQ helicase-like	BLM	functional
69	BCL2	B-cell CLL/lymphoma 2	BCL2	functional
74	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	HSP90AA1	functional
78	ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase	ABL1	functional,downstream
79	BRCA2	breast cancer 2, early onset	BRCA2	functional
80	TOP2A	topoisomerase (DNA) II alpha	TOP2A	functional
81	TOP2B	topoisomerase (DNA) II beta	TOP2B	functional
82	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	NFKB1	functional
83	TOP1	topoisomerase (DNA) I	TOP1	functional
84	RAD51	RAD51 recombinase	RAD51	cell,functional
92	ERCC6	excision repair cross-complementation group 6	ERCC6	functional
104	ERCC3	excision repair cross-complementation group 3	ERCC3	functional
105	TERF1	telomeric repeat binding factor (NIMA-interacting) 1	TERF1	functional
106	PRKDC	protein kinase, DNA-activated, catalytic polypeptide	PRKDC	functional
109	ERCC5	excision repair cross-complementation group 5	ERCC5	functional
113	PCNA	proliferating cell nuclear antigen	PCNA	functional
116	TERF2	telomeric repeat binding factor 2	TERF2	functional
117	XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	XRCC6	functional
199	HSPA8	heat shock 70kDa protein 8	HSPA8	functional
121	EMD	emerin	EMD	functional
126	XPA	xeroderma pigmentosum, complementation group A	XPA	functional,putative
128	RECQL4	RecQ helicase-like 4	RECQL4	functional
131	FOXM1	forkhead box M1	FOXM1	functional
135	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	AIFM1	functional
141	PRDX1	peroxiredoxin 1	PRDX1	functional,putative
147	RAD52	RAD52 homolog, DNA repair protein	RAD52	cell,functional
148	TOP3B	topoisomerase (DNA) III beta	TOP3B	functional,putative
149	ERCC1	excision repair cross-complementation group 1	ERCC1	mammal,functional
151	HDAC1	histone deacetylase 1	HDAC1	functional
153	GPX1	glutathione peroxidase 1	GPX1	functional
154	GSR	glutathione reductase	GSR	functional
155	GSS	glutathione synthetase	GSS	functional
156	GSTA4	glutathione S-transferase alpha 4	GSTA4	functional
157	GSTP1	glutathione S-transferase pi 1	GSTP1	functional
158	MT-CO1	mitochondrially encoded cytochrome c oxidase I	MT-CO1	cell,functional
159	HSPD1	heat shock 60kDa protein 1 (chaperonin)	HSPD1	functional
160	HSPA1A	heat shock 70kDa protein 1A	HSPA1A	mammal,model,functional,putative
161	HSPA1B	heat shock 70kDa protein 1B	HSPA1B	functional,putative
162	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	PCMT1	functional,putative
168	MAPK14	mitogen-activated protein kinase 14	MAPK14	cell,functional
181	LMNB1	lamin B1	LMNB1	functional
195	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	APEX1	functional
207	HDAC2	histone deacetylase 2	HDAC2	functional,upstream
208	MAX	MYC associated factor X	MAX	functional
209	MXD1	MAX dimerization protein 1	MXD1	functional
143	RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	RELA	functional
44	NBN	nibrin	NBN	functional,putative
212	H2AFX	H2A histone family, member X	H2AFX	functional
95	APTX	aprataxin	APTX	functional
88	CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	CEBPA	functional
232	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3	functional
236	POLB	polymerase (DNA directed), beta	POLB	functional
237	GCLC	glutamate-cysteine ligase, catalytic subunit	GCLC	functional
242	PMCH	pro-melanin-concentrating hormone	PMCH	functional
243	MLH1	mutL homolog 1	MLH1	functional,putative
247	CHEK2	checkpoint kinase 2	CHEK2	functional
252	CLOCK	clock circadian regulator	CLOCK	functional,downstream
254	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	PAPPA	mammal,functional,putative
261	ERCC4	excision repair cross-complementation group 4	ERCC4	functional,putative
263	PPARG	peroxisome proliferator-activated receptor gamma	PPARG	functional
269	SIRT7	sirtuin 7	SIRT7	functional,putative
271	SOCS2	suppressor of cytokine signaling 2	SOCS2	functional,upstream
274	TP53BP1	tumor protein p53 binding protein 1	TP53BP1	functional
275	SIRT3	sirtuin 3	SIRT3	functional
278	BAK1	BCL2-antagonist/killer 1	BAK1	functional
279	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	IGFBP2	mammal,functional
281	TP73	tumor protein p73	TP73	functional,putative
303	RICTOR	RPTOR independent companion of MTOR, complex 2	RICTOR	functional,putative
307	NFE2L1	nuclear factor, erythroid 2-like 1	NFE2L1	model,functional
305	TRAP1	TNF receptor-associated protein 1	TRAP1	functional,putative