Human Ageing-Associated Genes

HAGRID HGNC symbol Common name Display entry Source
1GHRgrowth hormone receptorGHRmammal
2GHRHgrowth hormone releasing hormoneGHRHmammal
3SHC1SHC (Src homology 2 domain containing) transforming protein 1SHC1mammal
4POU1F1POU class 1 homeobox 1POU1F1mammal
5PROP1PROP paired-like homeobox 1PROP1mammal
6TP53tumor protein p53TP53mammal,model,cell
7TERCtelomerase RNA componentTERCmammal,cell
9ATMATM serine/threonine kinaseATMmammal
10PLAUplasminogen activator, urokinasePLAUmammal
11ERCC2excision repair cross-complementation group 2ERCC2mammal
13WRNWerner syndrome, RecQ helicase-likeWRNhuman,mammal,cell
17KLklothoKLmammal
26GH1growth hormone 1GH1mammal,functional,downstream
61BRCA1breast cancer 1, early onsetBRCA1mammal
98HTThuntingtinHTTmammal
112XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)XRCC5mammal
127MSRAmethionine sulfoxide reductase AMSRAmammal,model
129SOD2superoxide dismutase 2, mitochondrialSOD2mammal,model
149ERCC1excision repair cross-complementation group 1ERCC1mammal,functional
150SIRT1sirtuin 1SIRT1mammal,model,cell
160HSPA1Aheat shock 70kDa protein 1AHSPA1Amammal,model,functional,putative
45JUNDjun D proto-oncogeneJUNDmammal,putative
101HELLShelicase, lymphoid-specificHELLSmammal
72POLGpolymerase (DNA directed), gammaPOLGmammal
197BUB1BBUB1 mitotic checkpoint serine/threonine kinase BBUB1Bmammal
89CEBPBCCAAT/enhancer binding protein (C/EBP), betaCEBPBmammal
219NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaNFKBIAmammal,putative
221MTORmechanistic target of rapamycin (serine/threonine kinase)MTORmammal,model,cell
226CDKN2Acyclin-dependent kinase inhibitor 2ACDKN2Amammal,cell
234TP63tumor protein p63TP63mammal
239SIRT6sirtuin 6SIRT6mammal
240BUB3BUB3 mitotic checkpoint proteinBUB3mammal
241RAE1ribonucleic acid export 1RAE1mammal
231ATRATR serine/threonine kinaseATRmammal
245STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligaseSTUB1mammal
249ARHGAP1Rho GTPase activating protein 1ARHGAP1mammal
251ARNTLaryl hydrocarbon receptor nuclear translocator-likeARNTLmammal
254PAPPApregnancy-associated plasma protein A, pappalysin 1PAPPAmammal,functional,putative
255ADCY5adenylate cyclase 5ADCY5mammal
256PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alphaPPARGC1Amammal,upstream,downstream
260EFEMP1EGF containing fibulin-like extracellular matrix protein 1EFEMP1mammal
264AGTR1angiotensin II receptor, type 1AGTR1mammal
265CISD2CDGSH iron sulfur domain 2CISD2mammal
266EEF1E1eukaryotic translation elongation factor 1 epsilon 1EEF1E1mammal
267EPS8epidermal growth factor receptor pathway substrate 8EPS8mammal
268KCNA3potassium channel, voltage gated shaker related subfamily A, member 3KCNA3mammal
270SLC13A1solute carrier family 13 (sodium/sulfate symporter), member 1SLC13A1mammal,model
273TPP2tripeptidyl peptidase IITPP2mammal
276NCOR2nuclear receptor corepressor 2NCOR2mammal
279IGFBP2insulin-like growth factor binding protein 2, 36kDaIGFBP2mammal,functional
289EIF5A2eukaryotic translation initiation factor 5A2EIF5A2mammal
290MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)MIFmammal
291DGAT1diacylglycerol O-acyltransferase 1DGAT1mammal
293FGF21fibroblast growth factor 21FGF21mammal
294HTRA2HtrA serine peptidase 2HTRA2mammal
295GSK3Aglycogen synthase kinase 3 alphaGSK3Amammal
296NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 1NUDT1mammal
297IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaIKBKBmammal
299CDK7cyclin-dependent kinase 7CDK7mammal
306TRPV1transient receptor potential cation channel subfamily V member 1TRPV1mammal
308IFNB1Interferon betaIFNB1mammal,cell
309GDF11growth differentiation factor 11GDF11mammal,human_link