GenAge entry for EGFR (Homo sapiens)
Gene name (HAGRID: 40)
- HGNC symbol
- EGFR
- Aliases
- ERBB1; ERBB
- Common name
- epidermal growth factor receptor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
EGFR is a glycoprotein and oncogene involved in cell proliferation. It has been associated with age-related declines in stress-response [1161], but it is not known whether this is a cause or effect of ageing. EGFR has also been related to age-related declines in rat hepatocytes [346]. Whether EGFR plays a role in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 7p12
- Location
- 55,019,032 bp to 55,207,338 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0001503; ossification
GO:0001892; embryonic placenta development
GO:0001934; positive regulation of protein phosphorylation
GO:0001942; hair follicle development
GO:0006412; translation
GO:0006950; response to stress
GO:0006970; response to osmotic stress
GO:0006979; response to oxidative stress
GO:0007165; signal transduction
And 78 more GO terms Cellular component: GO:0000139; Golgi membrane
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005768; endosome
GO:0005789; endoplasmic reticulum membrane
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0005925; focal adhesion
GO:0009986; cell surface
GO:0010008; endosome membrane
And 14 more GO terms
Show all GO termsFunction: GO:0001948; glycoprotein binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0004709; MAP kinase kinase kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888; transmembrane signaling receptor activity
GO:0005006; epidermal growth factor-activated receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005178; integrin binding
And 15 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TP53, IGF1R, TXN, PTPN11, STAT5B, STAT3, STAT5A, IRS1, PTPN1, IRS2, AKT1, PIK3CB, EGFR, ERBB2, NRG1, EGF, FOS, PDGFRB, RET, PLCG2, RPA1, BLM, HSP90AA1, ABL1, PML, HTT, PRKCA, PRKDC, AR, XRCC5, PCNA, HSPA8, EMD, GRB2, AIFM1, UCHL1, APP, PRDX1, HSPA1A, HSPA1B, MAPK8, YWHAZ, PTK2B, PTK2, MAPK14, MAPK9, PIK3R1, EEF1A1, JAK2, HSPA9, CDK1, CTGF, H2AFX, NR3C1, HELLS, CEBPB, ESR1, CLU, MTOR, CTNNB1, MAPT, GCLM, BUB3, ATR, STUB1, ARHGAP1, PPARGC1A, PPARG, EPS8, PDGFRA, GRN, TRPV1
- STRING interaction network
